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Symbol
Name
ID
Smc3
structural maintenance of chromosomes 3
MGI:1339795
Phenotype annotations related to nervous system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Primary microcephaly
Secondary microcephaly
Poor speech
Cognitive impairment
Intellectual disability
Global developmental delay
Seizure
Disease(s) Associated with SMC3
Cornelia de Lange syndrome 3

Mouse Phenotypes
nervous system phenotype
enlarged brain ventricles
decreased CNS synapse formation
abnormal dendritic mushroom spine morphology
decreased dendritic spine density
increased dendritic spine length
abnormal dendritic thin spine morphology
abnormal pyramidal neuron dendrite morphology
abnormal postsynaptic density morphology
Availability Mouse Genotype
Smc3tm1.2Toshi/Smc3+ *
Smc3tm1.1Toshi/Smc3tm1.1Toshi
Tg(Nes-cre/ERT2)#Kag/0  (conditional)
Smc3tm1.1Toshi/Smc3+
Mapttm2(cre)Aha/Mapt+  (conditional)
Smc3tm1.1Toshi/Smc3+
Tg(Icam5-cre)DYyos/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory