Symbol Name ID |
Smc3
structural maintenance of chromosomes 3 MGI:1339795 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Primary microcephaly |
Secondary microcephaly |
Poor speech |
Cognitive impairment |
Intellectual disability |
Global developmental delay |
Seizure |
Disease(s) Associated with SMC3 | |||||||
Cornelia de Lange syndrome 3 |
Mouse Phenotypes | nervous system phenotype |
enlarged brain ventricles |
decreased CNS synapse formation |
abnormal dendritic mushroom spine morphology |
decreased dendritic spine density |
increased dendritic spine length |
abnormal dendritic thin spine morphology |
abnormal pyramidal neuron dendrite morphology |
abnormal postsynaptic density morphology |
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Availability | Mouse Genotype | |||||||||
Smc3tm1.2Toshi/Smc3+ | * | |||||||||
Smc3tm1.1Toshi/Smc3tm1.1Toshi Tg(Nes-cre/ERT2)#Kag/0 (conditional) |
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Smc3tm1.1Toshi/Smc3+ Mapttm2(cre)Aha/Mapt+ (conditional) |
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Smc3tm1.1Toshi/Smc3+ Tg(Icam5-cre)DYyos/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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